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The specific interaction between small GTP binding protein Ras and its effector proteins is a typical example how cellular signal transduction is executed. The binding properties of the effector Nore1A to active K-Ras-GppNHp and to inactive K-Ras-GDP were analyzed with a label-free surface acoustic wave (SAW) sensor. The measured phase signal was used for the concomitant evaluation of the binding...
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