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Low O 2 levels in solid tumors are associated with increase in hypoxia-inducible factor 1α (HIF-1α). The present study examines functional changes involved in adaptation to hypoxia of the LMM3 mammary tumor cell line, using CoCl 2 as hypoxic mimetic. Our results showed that LMM3 cells were not only tolerant to 150μM CoCl 2 but they can overgrowth in vitro respect to untreated...
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