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After an allosteric transition produced by the binding of cyclic AMP (cAMP), the Escherichia coli catabolite gene activator protein (CAP) binds DNA specifically and activates transcription. The three-dimensional crystal structure of the CAP-cAMP complex has been refined at 2.1Å resolution, thus enabling a better evaluation of the structural basis for CAP phenotypes, the interactions of cAMP with CAP...
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