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Bacterial cold shock proteins (CSPs) are involved in cellular adaptation to cold stress. They bind to single-stranded nucleic acids with a K D value in the micro- to nanomolar range. Here we present the structure of the Bacillus subtilis CspB (Bs-CspB) in complex with hexathymidine (dT 6 ) at a resolution of 1.78 Å. Bs-CspB binds to dT 6 with nanomolar affinity via an amphipathic...
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