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We use a coarse-grained protein model to characterize the critical nucleus, structural stability, and fibril elongation propensity of Aβ 1–40 oligomers for the C 2x and C 2z quaternary forms proposed by solid-state NMR. By estimating equilibrium populations of structurally stable and unstable protofibrils, we determine the shift in the dominant population from free monomer...
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