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A potential region of drug-DNA interaction in the A subunit of DNA gyrase has previously been identified from crystallographic studies. The local amino acid sequence has been compared with similar regions in yeast topoisomerase II and human topoisomerase IIα. Three non-conserved, potentially solvent-accessible residues at positions 762, 763 and 766 in human topoisomerase IIα lie between well-conserved...
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