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The cap-binding protein eIF4E is the first in a chain of translation initiation factors that recruit 40S ribosomal subunits to the 5′ end of eukaryotic mRNA. During cap-dependent translation, this protein binds to the 5′-terminal m 7 Gppp cap of the mRNA, as well as to the adaptor protein eIF4G. The latter then interacts with small ribosomal subunit-bound proteins, thereby promoting the mRNA...
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