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A series of structural intermediates in the putative pathway from the cellular prion protein PrP C to the pathogenic form PrP Sc was established by systematic variation of low concentrations (<0.1%) of the detergent sodium dodecyl sulfate (SDS) or by the interaction with the bacterial chaperonin GroEL. Most extended studies were carried out with recombinant PrP (90-231) corresponding...
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