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Aβ40 and Aβ42 are the predominant Aβ species in the human body. Toxic Aβ42 oligomers and fibrils are believed to play a key role in causing Alzheimer's disease (AD). However, the role of Aβ40 in AD pathogenesis is not well established. Emerging evidence indicates a protective role for Aβ40 in AD pathogenesis. Although Aβ40 is known to inhibit Aβ42 fibril formation, it is not clear whether the inhibition...
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