The neuropeptide cholecystokinin (CCK) has been shown to interact with dopamine in various ways, including attenuation of dopamine D 1 receptor-mediated vacuous chewing and grooming. While we have demonstrated a clear role for the CCK A receptor in the attenuation of dopamine D 1 agonist-induced vacuous chewing, studies of grooming yielded anomolous results. We examined the effects of selective CCK receptor antagonists on the attenuation of SKF 38393-induced grooming by the CCK B agonist CCK-4. Administration of SKF 38393 (5 mg/kg s.c.) to male Sprague-Dawley rats resulted in a significant increase in grooming which was reduced to control levels by CCK-4 (20 mg/kg i.p.). Pretreatment with either the CCK A receptor antagonist devazepide or the CCK B receptor antagonist L-365,260 significantly attenuated this effect over a range of doses (20, 100, 500 μg/kg i.p.). The suppression of dopamine D 1 agonist-induced grooming by CCK-4 does not appear to reflect a non-specific effect of anxiogenesis, as it was unaffected by the anxiolytic diazepam. The CCK receptor antagonists alone were without behavioural effect. Taken together with previous studies in models of anxiety and analgesia, our findings lend further support to the hypothesis that CCK-4 may act at a novel receptor subtype.