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Endogenous endocannabinoids (ECs) (anandamide and 2-arachidonoyl glycerol) are part of the leptin-regulated neural circuitry involved in appetite regulation. One of the sites of the orexigenic action of ECs involves activation of cannabinoid-1 (CB 1 ) receptors in the lateral hypothalamus, from which neurons involved in mediating food reward project into the limbic system. In animal models...
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