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Hypoxic encephalopathy is a common cause of neonatal seizures and long-term neurological cognitive deficits. In rats at postnatal days 10–12 (P10–P12), global hypoxia induced spontaneous seizures and chronic brain injury, mimicking clinical aspects of neonatal hypoxia. Synaptic Ras-GTPase activating protein (SynGAP) has important roles in RAS/MAPK-dependent synaptic plasticity and mammalian learning...
The RNA-binding protein HuD binds to and stabilizes a number of neuronal-specific mRNAs. Recent work from our laboratory indicated that HuD expression is increased in neurons during peripheral nerve regeneration. To gain further insight into the function of this protein in CNS neurons we examined the levels of expression and localization of HuD in hippocampal neurons under normal conditions and in...
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