Oxidatively modified LDL appears to be important in the pathogenesis of coronary atherosclerosis and endothelial dysfunction by severe mechanism. Therefore, we measured the antioxidazed LDL autoantibodies of the patients received coronary angiography in our hospital in order to determine the relation both angiografical findings of the coronary artery and antioxidazed LDL autoantibody titers. We examined 119 consecutive patients (Male, 75; Female, 44; mean age, 58.2 y) who complaint the chest pain and were received the coronary angiography. The circulating levels of autoantibodies to oxidized LDL, lipids, Lp(a), coagulation factor VII, X, and fibrinogen were measured. And the other risk factors, such as hypertension, diabetes mellitus, obesity, and smoking were also discussed. In the three groups (normal coronary, 47 patients; stenosis, 47; spasm induced by acetylcholine and/or ergonovine, 25; by angiographical findings), a significant difference of the levels of antioxidazed LDL autoantibodies was observed between stenosis group and normal (P < 0.01). And in unstable angina, the levels of antioxidazed LDL autoantibodies were significantly higher than stable angina (stenosis group; P < 0.05, spastic group; P < 0.05). The relation between the levels of antioxidazed LDL autoantibodies and the other risk factors was not observed. Therefore, the levels of antioxidazed LDL autoantibodies may indicate coronary atherosclerosis and an urgent clinical state.