Cotyledonary explants from one seedling of Cucumis melo cv. Cantaloupe Charentais showed shoot regeneration capacity in a medium with a high auxin/cytokinin ratio. To date, in this medium, only growth of unorganized callus had been observed. From these shoots, a somaclone (GM, Genotype showing Morphogenic response) was obtained. Cotyledonary explants from 50% of the plants obtained from the self-fertilization of GM somaclone again showed shoot regeneration capacity in the high auxin/cytokinin ratio medium, while explants from plants of the control population did not. This fact proves a sexual transmission of this trait. Moreove, all leaf explants from the GM somaclone readily formed shoots when placed on a caulogenic medium. Leaf explants from plants of the control population showed a high variability in shoot regeneration capacity.