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Botulinum neurotoxins are multifaceted molecules, which are truly unique not only in their mode of action, but also in their utility as a drug carrier either across the gut wall or to the nerve terminals. The molecule is divided into clear functional domains that can operate independently. This feature can be used to employ them as cargo carrier by linking other drugs or vaccines with the binding...
For the first time the venom of recently established viper species Vipera nikolskii was fractionated and two heterodimeric phospholipases A 2 (HDP-1 and HDP-2) were isolated. Isolation of HDP-1 and HDP-2 is the first indication of the presence of two heterodimeric phospholipases A 2 in the venom of one viper species. When tested on the frog neuromuscular junction, isolated proteins...
Snake venom C-type lectin-like proteins (CLPs) are ubiquitously found in Viperidae snake venoms and differ from the C-type lectins as they display different biological activities but no carbohydrate-binding activity. Previous analysis of the transcriptome obtained from the Bothrops insularis venom gland showed the presence of two clusters homologous to bothrojaracin (BJC) chains α and β. In an effort...
A novel serine protease, ABUSV-SPase, was isolated to homogeneity for the first time from Chinese Agkistrodon blomhoffii ussurensis snake venom, and its enzymatic and structural properties were characterized by multiple techniques. ABUSV-SPase is a stable monomeric protein with a molecular mass of 26,752.6a.m.u. It reacts optimally with its substrate N α -tosyl-l-arginine methyl ester (TAME)...
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