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The present research concerns the use of botulinum neurotoxin serotype A (BoNT/A) in preventing hair loss and favoring hair regrowth in subjects suffering alopecia areata. The model used was the relatively common form of hair loss, which arises spontaneously in C57BL/6 (B6) and B6×129Sv substrains. These mice initiate losing their hairs at the 3rd–4rd month of age, predominantly in the head–neck region,...
Yessotoxin (YTX), an algal toxin contaminating edible shellfish, was previously shown to induce ultrastructural changes in some cardiac muscle cells of mice after acute (1 and 2mg/kg) or daily repeated oral exposure (1 and 2mg/kg/day, for 7 days). Therefore, the temporal evolution of the ultrastructural myocardial alterations and the development of other signs of toxicity induced by a repeated daily...
While many invertebrates sequester toxic compounds to endow eggs with chemical defences, here we show, for the first time to our knowledge, the identification of a neurotoxin of proteinaceous nature localized inside an egg.Egg extracts from the freshwater apple snail Pomacea canaliculata displayed a neurotoxic effect in mice upon intraperitoneal injection (i.p.) (LD50, 96h 2.3mg/kg). Egg protein and...
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