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Spider venoms have high specificity to neuronal elements. Therefore, the use of venom has been important in the characterisation of mammal and insect nervous systems. The evaluation of insect paralysis has been an important tool for distinguishing the biological effects of venom. In this study we describe the paralysing effect of a spider crude venom (Parawixia bistriata) in termites, utilising a...
The characterisation of the antimicrobial activity of five antibacterial peptides, isolated from the venom of the neotropical wandering spider Cupiennius salei is reported here. The peptides have a molecular mass, determined by electrospray ionisation-mass spectrometry, between 3-4<space>kDa. Minimal inhibitory concentrations against five different bacteria species were determined by a liquid...
The haemodynamic alterations induced by the central and peripheral administration of the armed spider (Phoneutria nigriventer) venom (PNV) were investigated in anaesthetised rabbits. The intracerebroventricular injection of increasing doses of PNV (30 and 100 μg/kg) elicited a biphasic cardiovascular response characterised by a brief hypotension (1-3 min) followed by a marked and sustained (more than...
This study compared the pharmacological activity of venom from male and female white-tailed spiders (L. cylindrata). In guinea-pig ileum, male L. cylindrata venom (1-10 μg/ml) caused dose-dependent contractions. The response to venom (5 μg/ml) was significantly inhibited by mepyramine (0.5 μM). Venom (5-50 μg/ml) from female L. cylindrata had no contractile activity in this tissue. However, female...
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