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In the present study, some biochemical properties and pathological effects of Daboia russelli venom from Burdwan district of West Bengal, eastern India are presented. The clinical features of Russell's viper envenomation observed in patients admitted to Burdwan Medical College & Hospital are also reported. In vitro, whole venom exerts strong trypsin inhibitory, phospholipase A 2 and procoagulant...
A toxic phospholipase A 2 (PLA 2 -H1), isolated from the venom of the sea snake Hydrophis cyanocinctus, was tested for its ability to induce myonecrosis and histopathological changes in albino rats and mice. Induction of myonecrosis was demonstrated by their ability to release creatine kinase (CK) from damaged muscle fibers and direct histopathological examination of the injected muscles...
The purified β phospholipase A 2 (PLA 2 ; EC 3.1.1.4) (PLA 2 ) from sea anemone (Aiptasia pallida) nematocysts is larger and more labile than other known venom PLA 2 s. In common with all other known venoms and most secretory PLA 2 s, the β PLA 2 requires mM Ca 2+ for optimal activity and is surface-activated by aggregated lipids such as...
Bothropstoxin-I (BthTX-I) and bothropstoxin-II (BthTX-II) are Lys-49 and Asp-49 phospholipases A 2 (PLA 2 s), respectively, isolated from Bothrops jararacussu venom. Piratoxin-I (PrTX-I) is a Lys-49 PLA 2 isolated from Bothrops pirajai venom. In this study, the ability of BthTX-I, BthTX-II and PrTX-I to recruit leucocytes into the rat pleural cavity and potential mechanisms...
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