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Phospholipase A 2 inhibitors (PLIs) are glycoproteins secreted by snake liver into the circulating blood aiming the self-protection against toxic venom phospholipases A 2 . In the present study, we describe the first complete nucleotide sequence of a βPLI from venom glands of a New World snake, Lachesis muta. The deduced primary structure was compared to other known βPLIs and recent...
Several sesquiterpene lactone were synthesized and their inhibitive activities on phospholipase A 2 (PLA 2 ) from Bothrops jararacussu venom were evaluated. Compounds Lac01 and Lac02 were efficient against PLA 2 edema-inducing, enzymatic and myotoxic activities and it reduces around 85% of myotoxicity and around 70% of edema-inducing activity. Lac05–Lac08 presented lower efficiency...
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