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ACL myotoxin (ACLMT) is a Lys49 phospholipase A 2 -like protein isolated from the venom of the snake Agkistrodon contortrix laticinctus. The aim of this work was to study the effect of ACLMT on water transport in the toad bladder. Water flow through the membrane was measured gravimetrically in bag preparations of the bladder. ACLMT (20nM) increased the baseline water flow and partially inhibited...
An Asp49 PLA 2 (ACL-I PLA 2 ) was purified from the venom of Agkistrodon contortrix laticinctus by gel filtration and cation-exchange chromatography. It has a relative molecular mass of 14,000, and its N-terminal sequence has more than 65% of identity with other snake venom PLA 2 s. ACL-I PLA 2 injected into the Tibialis anterior muscle of rats and mice at doses of...
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