Existence theory is developed for the equation ℓ(u)=F(u), where ℓ is a formally self-adjoint singular second-order differential expression and F is nonlinear. The problem is treated in a Hilbert space and we do not require the operators induced by ℓ to have completely continuous resolvents. Nonlinear boundary conditions are allowed. Also, F is assumed to be weakly continuous and monotone at one point. Boundary behavior of functions associated with the domains of definitions of the operators associated with ℓ in the singular case is investigated. A special class of self-adjoint operators associated with ℓ is obtained.