Case reports have been a valuable method of informing medical practice for as long as medicine has been practised. Many original observations, novel diagnostic and therapeutic approaches, unusual, new or uncommon diseases and complications of medical treatment were first identified and published as case reports. Despite their importance, and contemporary trends supporting their further use, publishing case reports can be a difficult task for many clinicians and researchers. Preparing a case report for publication can be both a professionally and personally rewarding endeavour for clinicians. This article describes practical and academic insights into writing a case report for publication.