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The binding capacity of FK506 binding protein (FKBP) was examined after 2-h hemispheric ischemia in the gerbil brain in order to clarify the precise mechanism of the neuroprotective effects of FK506. Firstly, the FK506 binding was evaluated in vitro in the normal gerbil brain using 1 nM [ 3 H]dihydro-FK506 as a specific ligand. FK506 binding sites were distributed in a rather homogeneous manner,...
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