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MPTP is a toxin presumed to damage dopamine-secreting neurons by an oxygen free radical-mediated mechanism. Two steps in MPTP metabolism are the primary candidates for oxygen free radical generation: (a) MPTP oxidation to MPP + by a monoamine oxidase and (b) NADH dehydrogenase inhibition by MPP + . In order to test the idea that MPTP toxicity is mediated by oxygen free radicals, we...
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