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Contralateral intrastriatal injection of 0.1 pmol or 1 pmol of endothelin-1 produced ipsilateral turning behaviour in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway. This effect could be abolished by pretreatment with either the endothelinET A/B receptor antagonist bosentan (1 nmol, intrastriatally) or the dopamine D 2 receptor antagonist raclopride...
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