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Treatment with lipopolysaccharide (LPS) for 72 h was shown to dose-dependently increase nitric oxide production from 6-day-old retinal cultures. Cell death, as determined by lactate dehydrogenase (LDH) release and an increase in neuronal labelling for TUNEL, was elevated concurrently. During treatment there was an increase of both inducible nitric oxide synthase and glial fibrillary acidic protein...
Gas6, a product of the growth-arrest-specific gene 6, protects cortical neurons from amyloid β protein (Aβ)-induced apoptosis. Neuronal apoptosis is also caused by human group IIA secretory phospholipase A 2 (sPLA 2 -IIA), which is expressed in the cerebral cortex after brain ischemia. sPLA 2 -IIA induces Ca 2+ influx via L-type voltage-sensitive calcium channels...
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