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The stress response involves the activation of two corticotropin-releasing factor (CRF) receptor subtypes. We investigated the role of CRF 1 in stress-related visceral responses. A novel water-soluble tricyclic CRF 1 antagonist, NBI 35965 was developed that displayed a high affinity for CRF 1 (K i ~4 nM) while having no binding affinity to CRF 2 . This antagonist...
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