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The chronotropic effects of metoprolol (MP) in vivo after intravenous administration and in vitro in isolated atria of aortic coarctated rats were studied. MP levels in arterial dialysates and changes in arterial pressure and heart rate (HR) were determined after intravenous administration of MP. Affinity of MP by means of shifting of noradrenaline concentration-response curve and the inverse agonist...
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