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The effect of calcium channel blockers on foot shock induced (aggression (FSA) were studied in mice. Verapamil, (10, 20 and 40 mgkg −1 i.p.) diltiazem (20 and 40mgkg −1 i.p.) and nifedipine (25 and 50 mgkg −1 i.p.) significantly reduced fighting episodes. Diltiazem and nifedipine blocked the amphetamine induced facilitation of FSA, while verapamil blocked both amphetamine as...
Calcium ionophore A23187 or phenylephrine injected i.p. in doses of 0.05–0 .25 mg kg −1 and 0.1–1 mg kg −1 , respectively, induced translocation of protein kinase C (PKC) from the cytosol to the membrane fraction of the rat frontal cortex and hippocampus. The action of A23187 was blocked in a dose-dependent manner by nifedipine and verapamil. The phenylephrine induced translocation...
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