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The present study was designed to investigate the possible modulator effect of melatonin on uterine estrogen and progesterone receptors in rats as well as the uterine response to oxytocin. Non-pregnant rats were pretreated with melatonin in a dose of 0.8mgkg -1 per day for 15 consecutive days. Control animals received the vehicle. The uterus was dissected out and uterine contraction in...
γ-Vinyl GABA (vigabatrin; VGB), an irreversible inhibitor of GABA-transaminase, was evaluated for its effect on the contractile responses to PGE 2 or its precursor arachidonic acid (AA) in guinea pig ileum (GPI) and non-pregnant rat uterus. Rationale behind this study was the rise in γ-aminobutyric acid (GABA) contents in the peripheral organs after treatment with GABAergic agents and extensive...
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