Objective: To report two cases of testicular cancer in patients presenting with infertility.Design: Case reports.Setting: University-affiliated urology practice.Patient(s): Two men presenting with infertility.Intervention(s): Complete history and physical, hormonal assays, semen analysis, scrotal ultrasound, radical orchiectomy.Main Outcome Measure(s): Testicular pathology specimens.Result(s): Testicular cancer was diagnosed in two men sent to a urology clinic for infertility treatment.Conclusion(s): A thorough evaluation should be completed in all males in couples presenting with infertility.