The main objective of this study was to test an innovative biomitigation approach, where polychaete-assisted (Hediste diversicolor) sand filters were combined with the production of Halimione portulacoides in aquaponics, to remediate an organic-rich effluent generated by a super intensive fish farm operating a land-based RAS (Recirculating aquaculture system). The set up included four different experimental combinations that were periodically monitored for 5months. After this period, polychaete-assisted sand filters reduced in 70% the percentage of OM and the average densities increased from ≈400ind.m−2 to 7000ind.m−2. H. portulacoides in aquaponics contributed to an average DIN (Dissolved inorganic Nitrogen) decrease of 65%, which increased to 67% when preceded by filter tanks stocked with polychaetes. From May until October (5months) halophytes biomass increased from 1.4kgm−2±0.7 (initial wet weight) to 18.6kgm−2±4.0. Bearing in mind that the uptake of carbon is mostly via photosynthesis and not though the uptake of dissolved inorganic carbon, this represents an approximate incorporation of ≈1.3kgm−2 carbon (C), ≈15gm−2 nitrogen (N) and ≈8gm−2 phosphorus (P) in the aerial part (76% of total biomass), and an approximate incorporation of ≈0.5kgm−2 carbon (C), ≈3gm−2 nitrogen (N) and ≈2gm−2 phosphorus (P) in the roots (24% of total biomass). In the present study, the potential of the two extractive species for biomitigation of a super-intensive marine fish farm effluent could be clearly demonstrated, contributing in this way to potentiate the implementation of more sustainable practices.