Persons with mental illness have been routinely stigmatized and pushed out of the mainstream of society. This has resulted in inhumane treatment of persons with mental illness and has often led to exacerbation of problematic symptoms.This paper discusses the articles included in this special issue of Cognitive and Behavioral Practice addressing the hardship that social stigma places on persons with mental illness, as well as strategies for addressing the problem of stigma. Comments are made regarding each of these articles. Additional comments are made regarding the role that mental health professionals can and do play in the minimization of stigma.