The selective reduction of NO by C 3 H 8 is performed on copper-based catalysts, fresh and hydrothermally Cu-MFI with various Si/Al ratios and copper contents, Cu on conventional nonzeolitic supports with various Cu loadings. In the literature it is already known that the C 3 H 8 oxidation by NO occurs mainly on isolated copper ions. However, the sites responsible for the C 3 H 8 oxidation by O 2 are less studied. This note shows that nonisolated copper ions are active for the C 3 H 8 oxidation by O 2 . With or without NO in the feed, bulk oxides are more active for the C 3 H 8 -O 2 reaction than for the C 3 H 8 -NO (or NO 2 ) reaction. Furthermore, NO inhibits the hydrocarbon combustion by O 2 .