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Investigations were carried out to evaluate the hypoglycaemic activity of the infusion of Globularia alypum leaves. Oral and intraperitoneal administration of the plant (0.7 g/kg) produced a significant hypoglycaemic effect in normal as well as in hyperglycaemic rats. The infusion increased plasma insulin levels significantly in normal rats. It is suggested that the hypoglycaemic activity of this plant may be mediated through enhancement of peripheral metabolism of glucose and increase in insulin release.