Fuel development for the Reduced Enrichment for Research and Test Reactors (RERTR) program has demonstrated that U–Mo alloys in contact with Al develop interaction regions with phases that have poor irradiation behavior. The addition of Si to the Al has been considered with positive results. In this study, compositional modification is considered by replacing Si with Ge to determine the effect on the phase development in the system. The microstructural and phase development of a diffusion couple of U–7wt.% Mo in contact with Al–7wt.% Ge was examined by transmission electron microscopy, scanning electron microscopy and energy dispersive spectroscopy. The interdiffusion zone developed a microstructure that included the cubic-UGe 3 phase and amorphous phases. The UGe 3 phase was observed with and without Mo and Al solid solution developing a (U,Mo)(Al,Ge) 3 phase.