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We have determined the solution conformation of the major B cell epitope (residues 123–145, adrl23 hereafter) in the preS2 region of hepatitis B virus known to be associated with infection neutralization. The adrl23 shows an “L” shaped helix-turn-helix topology with two β-turns formed by residues Ala 130 -Asp 133 and Asp 133 -Val 136 intervening the N- and C-terminal...
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