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TGF-β and FAK modulate cell migration, differentiation, proliferation and apoptosis, and TGF-β promotes FAK transcription in intestinal epithelial cells via Smad-dependent and independent pathways. We utilized a 1320 bp FAK promoter-luciferase construct to characterize basal and TGF-β-mediated FAK gene transcription in IEC-6 cells. Inhibiting JNK or Akt negated TGF-β-stimulated promoter activity;...
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