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The goal of the present study was to determine whether endogenous synthesis of n−3 polyunsaturated fatty acids (PUFA) in the fat-1 mouse is comparable to fish oil feeding with respect to kidney n−3 PUFA composition and eicosanoid levels. Wild-type and heterozygous fat-1 mice, capable of synthesizing n−3 PUFA endogenously, were given diets enriched in either n−3 or n−6 PUFA in a 2×2 factorial design...
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