The microscopic mechanisms of O 2 diffusion in compressively strained high-density silicon oxides are investigated based on first-principles total-energy calculations. It is found that, both in high-density α-quartz and in α-cristobalite, the calculated incorporation energies and energy barriers increase with increase of oxide density. Independent of the structure of oxides, the calculated activation energies increase with increasing density. Furthermore, the calculated activation volumes suggest that the oxidation retardation by the oxidation-induced strain is due to the retardation of O 2 diffusion in the high-density region, qualitatively consistent with experimental results.