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We previously found that human chymase cleaves big endothelins (ETs) at the Tyr 31 -Gly 32 bond and produces 31-amino acid ETs (1-31), without any further degradation products. In the present study, we investigated the effects of various antioxidants on the ET-1 (1-31)-induced change in intracellular signaling and proliferation of cultured rat aortic smooth muscle cells (RASMC)...
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