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In the present study, the participation of the Na V 1.8 sodium channel was investigated in the development of the peripheral pro-nociceptive state induced by daily intraplantar injections of PGE 2 in rats and its regulation in vivo by protein kinase A (PKA) and protein kinase C epsilon (PKCɛ) as well. In the prostaglandin E 2 (PGE 2 )-induced persistent hypernociception,...
mGluR1 receptors are believed to play major roles in the pathophysiology of diseases such as anxiety and chronic pain and are being actively investigated as targets for drug development. Sequence polymorphisms can potentially influence the efficacy of drugs in patient populations and are therefore an important consideration in the drug development process. To identify DNA sequence variants of the...
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