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Ulcerative colitis is characterized by severe damage of the colon epithelium. Wnt-signaling is important for repair and regeneration of the intestinal epithelium. Lithium activates Wnt-signaling through inhibition of Glycogen Synthase Kinase 3β. Lithium induced prolonged remission in a patient with a bipolar disorder and ulcerative colitis, suggesting a therapeutic potential for ulcerative colitis...
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