In this study, comparative investigation of (i) untreated Ti–6Al–4V alloy, (ii) nanoporous thin TiO 2 layer formed by controlled anodic oxidation and (iii) electrodeposited hydroxyapatite coatings into porous oxide layer was carried out for evaluation of sliding-wear performances in a bio-simulated environment. Wear mechanisms, wear volumes and friction coefficients of the three types of surfaces under lubricated conditions in a bio-simulated solution were recorded and analyzed. The results presented herein show that, under the investigated tribocorrosion conditions (under reciprocating sliding), both surface treatments applied have improved the wear resistance and friction coefficients as compared to the untreated Ti–6Al–4V alloy surface.