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Spatial sensing in Dictyostelium involves localization of the phosphoinositide lipids PI(3,4,5)P 3 and PI(3,4)P 2 at the leading edge of the cell in response to an external gradient. We have previously proposed a modelling framework describing the regulation of these lipids by the enzymes PI3K and PTEN. In this paper we analyse this regulation from an input–output perspective. When...
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