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Short-term effects of growth hormone on bone metabolism and soft tissue collagen metabolism during weight loss in obese subjects on a very low calorie diet were investigated in a double-blind, placebo-controlled design. Twenty healthy, obese women (body mass index between 33 and 45 kg/m 2 ) aged 21–48 yr were followed for 8 wk: half received growth hormone. A 740-kcal diet was administered...
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