In this paper a robust and optimal attitude control design that uses the minimal kinematic parameters and angular velocities feedback is presented for the three-axis attitude stabilization of spacecraft with inertia uncertainties. After proposing a new class of robust attitude control laws for the three-axis attitude stabilization of spacecraft with inertia uncertainties, it is shown that the proposed robust attitude control laws are optimal with respect to performance indices. A numerical example is given to illustrate the theoretical results presented in this paper.