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We report a heteroplasmic novel mutation m.5636T>C in the mt-tRNA Ala in a patient with bilateral ptosis and ophthalmoparesis in whom a muscle biopsy showed cytochrome c oxdidase (COX) negative and ragged red fibers. Using laser capture microdissection we have isolated COX negative fibers and COX positive fibers from the muscle of the patient and determined that the mutation load was clearly...
To investigate the set of mtDNA molecules contained in small biological structures, powerful techniques for separation are required. We tested flow cytometry (FCM 1 1Flow cytometry.), laser capture microdissection (LCM 2 2Laser capture microdissection.) and a method using optical tweezers (OT 3 3Optical tweezers.) in combination with a 1μ-Ibidi-Slide with regard to their ability...
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