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To elucidate the effects of Sho-saiko-to extract and its components, baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, against the effects of longer periods of acute hepatic injury induced by CCl 4 , we measured serum ALT activity in male Wistar rats for five days after ip administration of CCl 4 (0.2 ml/kg), and examined the daily changes of the pharmacokinetic behavior of...
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