Bioconversion of l-phenylalanine to 2-phenylethanol using Saccharomyces cerevisiae is connected with the growth of biomass which is strongly limited by product inhibition. Therefore, fermentation can proceed only at low conversions of l-phenylalanine with very low yield of the desired product. Maximal concentration of 2-phenylethanol in an ordinary batch, fed-batch or chemostat bioreactor achieves the values of about 4gL −1 . The main aim of the present work was to study possible yield increase achieved by continuous separation of 2-phenylethanol such as membrane based solvent extraction (membrane extraction) and cross-flow microfiltration interconnected with a bioreactor in one hybrid system. In this part of the research, membrane extraction of 2-phenylethanol from aqueous phase to alkanes was examined using two different types of hollow fiber membrane modules. The measured extraction kinetics was compared with that obtained by the mathematical model of the membrane extraction at different operational parameters using the partition coefficient of 2-phenylethanol determined by equilibrium experiments. The air-lift reactor was connected with a ceramic multi-channel microfiltration module to study the impact of feed pumping to the microfiltration unit on the air-lift reactor hydrodynamics as well as the influence of different values of biomass concentration, transmembrane pressure, cross-flow velocity and bubbles dragging in the microfiltration unit on the steady-state permeate flux.